Segue abaixo as recomendações do guideline da ASCO sobre tromboprofilaxia ambulatoriais em pacientes com câncer:
Recommendation 2.2. High-risk outpatients with cancer (Khorana score of 2 or higher prior to starting a new systemic chemotherapy regimen) may be offered thromboprophylaxis with apixaban, rivaroxaban, or low-molecular-weight heparin (LMWH) provided there are no significant risk factors for bleeding and no drug interactions. Consideration of such therapy should be accompanied by a discussion with the patient about the relative benefits and harms, drug cost, and duration of prophylaxis in this setting (Type: evidence based; Evidence quality: intermediate to high for apixaban and rivaroxaban, intermediate for LMWH; Strength of recommendation: moderate).
Recommendation 2.3. Patients with multiple myeloma receiving thalidomide- or lenalidomide-based regimens with chemotherapy and/or dexamethasone should be offered pharmacologic thromboprophylaxis with either aspirin or LMWH for lower-risk patients and LMWH for higher-risk patients (Type: evidence based; Evidence quality: intermediate; Strength of recommendation: strong).